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News New technique speeds up mutation discovery in cancer tissues

Article in 'News' Written by Arul Prakash Published Dec 3, 2013

  1. Researchers have found a new technique to analyse cancer tissue samples for mutations making the process less time consuming and cost effective than before.

    Today, cancer diagnostics is time consuming and requires laborious molecular level analysis to treat patients based on mutations in their cancer tissues, as cancer drugs will not be effective without knowing the mutation status of patient. However, the process of extracting tumour samples and examining them with DNA analysis is hard and isn't accurate enough as samples with lower number of mutated cells could be missed.

    A new study published on Oncotarget researchers has shown a new technique to directly visualise mutations in sections of tumour tissues allowing pathologists to evaluate and make a cancer diagnosis with just a microscope. The technique is accurate even with lower mutated cells and the data can be extrapolated to predict the growth of tumour cells.

    One interesting application for the technology is that you can discover small groups of cancer cells with mutations that render them unresponsive to certain cancer drugs, and adapt the cancer treatment accordingly, says Prof Johan Botling from Uppsala University.

    The technique has proved to be accurate and correct during tests using large number of clinical samples. If adopted the method can certainly speed up cancer diagnosis and in turn offer a better cancer treatment.

    Further reading : In situ mutation detection and visualization of intratumor heterogeneity for cancer research and diagnostics.
    Grundberg I, Kiflemariam S, Mignardi M, Imgenberg-Kreuz J, Edlund K, Micke P, Sundström M, Sjöblom T, Botling J, Nilsson M.
    • Arul Prakash

      Article by Arul Prakash

      Editor and founder of BiotechCareer.Org. He is an Industrial Biotechnologists and also a web developer, gooner, blogger, and foodie.

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