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News Researchers discover why adverse cardiovascular events peak in the morning

Article in 'News' Written by Arul Prakash Published Nov 12, 2013

  1. Researchers discover that your body's internal biological clock might be the reason behind peak cardiovascular events and stoke in the morning.

    With the increase in obesity and unhealthy diets the number of fatalities due to cardiac arrests and other cardiovascular diseases among both sexes have leapfrogged to be the number one cause of death. In a new study published on Blood journal, research team from Brigham Women's Hospital and Oregon Health and Science University had revealed that the peak in adverse cardiovascular events observed in the morning may be related to internal body clock.

    "Our findings suggest that the circadian system, or the internal body clock, contributes to the increased risk for cardiovascular events in the morning," said Dr. Frank A.J.L. Scheer, director of the Medical Chronobiology Program at BWH.

    In a 2 week study designed to observe daily behavioral and environmental rhythms, researchers monitored 12 adults at BWH. Additionally, they were also studying breakdown of blood clots by Plasminogen activator inhibitor-1 (PAI-1). A major risk factor for blood clotting and one of the major contributors to heart attack and ischemic stroke.

    Researchers were trying to uncover whether altered posture, internal circadian rhythm or other physical activities had any influence on the increased levels of PAI-1 observed in the morning They observed that PAI-1 circulation peaked at around 6.30 am in adults with a regular sleep/wake up cycle.

    "Our findings indicate that the human circadian system causes a morning peak in circulating levels of PAI-1, independent of any behavioral or environmental influences," explained Dr. Steven Shea,director of the Oregon Institute of Occupational Health Sciences. "Indeed, the circadian system determined to a large extent the PAI-1 rhythm observed during a regular sleep/wake cycle. This morning peak in PAI-1 could help explain adverse cardiovascular events in vulnerable individuals."

    Reference ; Human circadian system causes morning peak in pro-thrombotic plasminogen activator inhibitor-1 (PAI-1) independent of sleep/wake cycle
    Frank A.J.L. Scheer, and Steven A. Shea
    • Arul Prakash

      Article by Arul Prakash

      Editor and founder of BiotechCareer.Org. He is an Industrial Biotechnologists and also a web developer, gooner, blogger, and foodie.

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